{"id":2953,"date":"2023-11-15T09:24:38","date_gmt":"2023-11-15T09:24:38","guid":{"rendered":"https:\/\/oligox.abtvn.com\/?p=2953"},"modified":"2023-12-05T09:39:42","modified_gmt":"2023-12-05T09:39:42","slug":"oligonucleotide-dendrimer","status":"publish","type":"post","link":"https:\/\/oligox.abtvn.com\/en\/oligonucleotide-dendrimer\/","title":{"rendered":"OLIGONUCLEOTIDE DENDRIMER<\/strong>"},"content":{"rendered":"\n

Oligonucleotide dendrimer \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng m\u1ed9t h\u1ee3p ch\u1ea5t phosphoramidite, tris-2,2,2-[3-(4,4′-dimethoxytrityloxy) propyloxymethyl]ethyl- N , N -diisopropylaminocyanethoxy phosphoramidite.<\/p>\n\n\n\n

Misha Shchepinov \u0111\u1ecbnh ngh\u0129a dendrimers l\u00e0 c\u00e1c lo\u1ea1i polymer r\u1eddi v\u00e0 c\u00f3 nhi\u1ec1u nh\u00e1nh n\u00ean \u0111\u01b0\u1ee3c v\u00ed nh\u01b0 c\u00e1c nh\u00e1nh c\u1ee7a c\u00e2y. Misha Shchepinov \u0111\u1eb7t gi\u1ea3 thuy\u1ebft r\u1eb1ng oligonucleotide dendrimer s\u1ebd l\u00e0 \u0111\u1ea1i di\u1ec7n cho m\u1ed9t \u0111o\u1ea1n (segment) m\u1edbi trong ng\u00e0nh khoa h\u1ecdc polymer trong t\u01b0\u01a1ng lai. <\/p>\n\n\n\n

\"H\u00ecnh
H\u00ecnh 1. <\/em><\/strong>Qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh c\u00e1c ph\u1ee9c h\u1ee3p ph\u00e2n nh\u00e1nh t\u01b0\u01a1ng h\u1ed7<\/em>.
(Ngu\u1ed3n: Glen Research)<\/figcaption><\/figure>\n\n\n\n

C\u00e1c ph\u00e2n t\u1eed DNA \u0111\u01b0\u1ee3c xem r\u1ea5t th\u00edch h\u1ee3p khi \u1ee9ng d\u1ee5ng trong c\u00f4ng ngh\u1ec7 nano do c\u00e1c \u0111\u1eb7c t\u00ednh \u0111\u1eb7c bi\u1ec7t c\u1ee7a ch\u00fang trong vi\u1ec7c nh\u1eadn bi\u1ebft ph\u00e2n t\u1eed. V\u00ed d\u1ee5, dendrimers v\u1edbi c\u00e1c nh\u00e1nh k\u1ebft th\u00fac \u1edf oligonucleotides trong c\u00f9ng m\u1ed9t ho\u1eb7c chu\u1ed7i kh\u00e1c nhau c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e2y d\u1ef1ng c\u00e1c c\u1ea5u tr\u00fac 3D ph\u1ee9c t\u1ea1p nh\u01b0 cryptands, \u1ed1ng, l\u01b0\u1edbi, k\u1ebft c\u1ea5u khung, v.v (H\u00ecnh 1)<\/em><\/strong>. Trong oligonucleotide arrays, n\u01a1i t\u00edn hi\u1ec7u ban \u0111\u1ea7u b\u1ecb gi\u1edbi h\u1ea1n b\u1edfi m\u1eadt \u0111\u1ed9 b\u1ec1 m\u1eb7t, s\u1ef1 \u0111a d\u1ea1ng c\u1ee7a vi\u1ec7c \u0111\u00e1nh d\u1ea5u do c\u1ea5u tr\u00fac dendritic gi\u00fap ph\u00e1t hi\u1ec7n \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p h\u01a1n. <\/p>\n\n\n\n

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Trong tr\u01b0\u1eddng h\u1ee3p s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00e1nh d\u1ea5u hu\u1ef3nh quang, c\u00e1c c\u1ea5u tr\u00fac dendritic n\u00e0y gi\u00fap l\u00e0m t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng ph\u00e1t hi\u1ec7n t\u00edn hi\u1ec7u, \u0111\u1ed3ng th\u1eddi duy tr\u00ec kho\u1ea3ng c\u00e1ch \u0111\u1ee7 gi\u1eefa c\u00e1c nh\u00e3n \u0111\u1ec3 tr\u00e1nh hi\u1ec7n t\u01b0\u1ee3ng t\u1ef1 d\u1eadp t\u1eaft (self-quenching), l\u00e0m cho qu\u00e1 tr\u00ecnh ph\u00e2n t\u00edch tr\u1edf n\u00ean hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 ch\u00ednh x\u00e1c h\u01a1n. T\u01b0\u01a1ng t\u1ef1, vi\u1ec7c \u0111\u00e1nh d\u1ea5u dendritic c\u1ee7a c\u00e1c \u0111\u1ea7u d\u00f2 cho ph\u00e9p t\u0103ng c\u01b0\u1eddng t\u00edn hi\u1ec7u m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chu\u1ed7i c\u01a1 b\u1ea3n c\u1ee7a \u0111\u1ea7u d\u00f2 oligonucleotide (H\u00ecnh 2<\/em>)<\/strong>.<\/p>\n\n\n\n

\"H\u00ecnh
H\u00ecnh 2. <\/em><\/strong>Qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i chu\u1ed7i primer PCR th\u00e0nh PCR s\u1ee3i \u0111\u01a1n<\/em>
(Ngu\u1ed3n: Glen Research)<\/figcaption><\/figure>\n\n\n\n

1. Oligonucleotide Dendrimer nh\u00e1nh \u0111\u1ed1i x\u1ee9ng<\/strong><\/h2>\n\n\n\n

Hi\u1ec7n nay, c\u00e1c c\u1ea5u tr\u00fac dendrimer \u0111\u1ed1i x\u1ee9ng \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p d\u1ec5 d\u00e0ng b\u1eb1ng s\u1eed d\u1ee5ng phosphoramidite t\u1ea1i m\u1ed9t s\u1ed1 h\u00e3ng nh\u01b0 GLEN Research, gi\u00fap nh\u00e2n \u0111\u00f4i c\u00e1c nh\u00e1nh trong chu\u1ed7i oligonucleotide \u0111ang t\u1ed5ng h\u1ee3p trong m\u1ed7i l\u1ea7n th\u00eam v\u00e0o. C\u00e1c nh\u00e1nh ph\u1ee9c t\u1ea1p h\u01a1n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng c\u00e1ch t\u0103ng g\u1ea5p \u0111\u00f4i 5′ termini nh\u01b0 minh h\u1ecda trong H\u00ecnh 3.<\/p>\n\n\n\n

\"H\u00ecnh
H\u00ecnh 3. <\/em><\/strong>V\u00ed d\u1ee5 v\u1ec1 c\u1ea5u tr\u00fac ph\u00e2n nh\u00e1nh \u0111\u01a1n v\u00e0 k\u1ebft h\u1ee3p \u1edf c\u00e1c th\u1ebf h\u1ec7 kh\u00e1c nhau<\/em>
(Ngu\u1ed3n: Glen Research)<\/figcaption><\/figure>\n\n\n\n

Khi m\u1eadt \u0111\u1ed9 c\u1ee7a oligo t\u0103ng tr\u00ean gi\u00e1 th\u1ec3 r\u1eafn, hi\u1ec7n t\u01b0\u1ee3ng c\u1ea3n tr\u1edf kh\u00f4ng gian (steric hindrance) l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh ph\u1ea3n \u1ee9ng, \u0111i\u1ec1u n\u00e0y gl\u00e0m cho c\u00e1c ph\u1ea3n \u1ee9ng tr\u1edf n\u00ean ch\u1eadm l\u1ea1i. Do \u0111\u00f3, c\u00f3 th\u1ec3 c\u1ea7n t\u1ed1i \u01b0u h\u00f3a m\u1ed9t s\u1ed1 chu k\u1ef3 t\u1ed5ng h\u1ee3p cho oligonucleotide dendritic ph\u1ee9c t\u1ea1p h\u01a1n. \u0110\u1ec3 \u0111\u1ea3m b\u1ea3o hi\u1ec7u su\u1ea5t t\u1ed1t nh\u1ea5t, qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean h\u1ed7 tr\u1ee3 r\u1eafn c\u00f3 k\u00edch th\u01b0\u1edbc \u00edt nh\u1ea5t l\u00e0 1000\u00c5 CPG v\u00e0 t\u1ed1t nh\u1ea5t l\u00e0 2000\u00c5 CPG cho c\u00e1c dendrimer ph\u1ee9c t\u1ea1p h\u01a1n.<\/p>\n\n\n\n

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2. Oligonucleotide Dendrimer nh\u00e1nh kh\u00f4ng \u0111\u1ed1i x\u1ee9ng<\/strong><\/h2>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn ph\u1ed5 bi\u1ebfn nh\u1ea5t \u0111\u1ed1i v\u1edbi ch\u1ea9n \u0111o\u00e1n DNA l\u00e0 khu\u1ebfch \u0111\u1ea1i chu\u1ed7i m\u1ee5c ti\u00eau \u0111\u1ec3 t\u1ea1o ra \u0111\u1ee7 b\u1ea3n sao cho t\u00edn hi\u1ec7u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c thu \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c h\u1ec7 th\u1ed1ng ph\u00e1t hi\u1ec7n truy\u1ec1n th\u1ed1ng. Tuy nhi\u00ean, c\u00f3 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c – ph\u00e2n t\u00edch tr\u1ef1c ti\u1ebfp c\u1ee7a DNA m\u1ee5c ti\u00eau th\u00f4ng qua t\u0103ng c\u01b0\u1eddng t\u00edn hi\u1ec7u. K\u1ef9 thu\u1eadt n\u00e0y y\u00eau c\u1ea7u oligonucleotide t\u1ed5ng h\u1ee3p n\u00ean ch\u1ee9a chu\u1ed7i tr\u00ecnh t\u1ef1 s\u01a1 c\u1ea5p \u0111\u01b0\u1ee3c g\u1eafn k\u1ebft v\u1edbi nhi\u1ec1u b\u1ea3n sao gi\u1ed1ng nhau c\u1ee7a chu\u1ed7i th\u1ee9 c\u1ea5p. Vi\u1ec7c ph\u00e1t hi\u1ec7n nhi\u1ec1u b\u1ea3n sao c\u1ee7a chu\u1ed7i th\u1ee9 c\u1ea5p l\u00e0m khu\u1ebfch t\u00e1n t\u00edn hi\u1ec7u. S\u1ea3n ph\u1ea9m oligom\u1ea1ch nh\u00e1nh \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 nh\u01b0 c\u00e2y l\u01b0\u1ee3c (c\u1ea5u tr\u00fac comb-like), v\u1edbi chu\u1ed7i s\u01a1 c\u1ea5p \u0111\u01b0\u1ee3c v\u00ed nh\u01b0 ph\u1ea7n tay c\u1ea7m v\u00e0 chu\u1ed7i th\u1ee9 c\u1ea5p l\u00e0 r\u0103ng l\u01b0\u1ee3c. C\u00e1c phosphoramidite kh\u00f4ng \u0111\u1ed1i x\u1ee9ng \u0111\u01b0\u1ee3c d\u00f9ng trong t\u1ed5ng h\u1ee3p c\u1ea5u tr\u00fac comb-like.<\/p>\n\n\n\n

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\"dummy-img\"<\/a><\/div><\/div>
B\u00e0i vi\u1ebft<\/a>\u1ee8ng d\u1ee5ng s\u1ea3n ph\u1ea9m<\/a><\/div><\/div>

Pannel \u1ee9ng d\u1ee5ng trong ch\u1ea9n \u0111o\u00e1n Thalassemia<\/a><\/h3>
\n \n \n<\/svg>\nadmin<\/a><\/span>\n \n<\/svg>\nAug 26, 2025<\/span>\n \n \n<\/svg>\n18 min read<\/span><\/div>

T\u1ed5ng quan Thalassemia Gi\u1edbi thi\u1ec7u Thalassemia Thalassemia (hay c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi v\u1edbi t\u00ean b\u1ec7nh tan m\u00e1u b\u1ea9m sinh) l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd huy\u1ebft h\u1ecdc di truy\u1ec1n c\u00f3 t\u1ef7 l\u1ec7 l\u01b0u h\u00e0nh cao tr\u00ean to\u00e0n c\u1ea7u v\u00e0 l\u00e0 m\u1ed9t v\u1ea5n \u0111\u1ec1…<\/p>\n<\/div>

Read More\n \n<\/svg>\n<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
\"\u1ea2nh<\/a><\/div><\/div>
B\u00e0i vi\u1ebft<\/a>\u1ee8ng d\u1ee5ng s\u1ea3n ph\u1ea9m<\/a><\/div><\/div>

\u1ea2nh h\u01b0\u1edfng c\u1ee7a TaqMan probe \u0111\u1ebfn \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u v\u00e0 \u0111\u1ed9 nh\u1ea1y trong Realtime PCR<\/a><\/h3>
\n \n \n<\/svg>\nadmin<\/a><\/span>\n \n<\/svg>\nMay 27, 2025<\/span>\n \n \n<\/svg>\n26 min read<\/span><\/div>

TaqMan Probe \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong vi\u1ec7c \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 ch\u00ednh x\u00e1c, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u v\u00e0 \u0111\u1ed9 nh\u1ea1y c\u1ee7a ph\u1ea3n \u1ee9ng trong k\u1ef9 thu\u1eadt Real-time PCR<\/p>\n<\/div>

Read More\n \n<\/svg>\n<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
\"TAQMAN<\/a><\/div><\/div>
B\u00e0i vi\u1ebft<\/a>\u1ee8ng d\u1ee5ng s\u1ea3n ph\u1ea9m<\/a><\/div><\/div>

TAQMAN PROBE V\u00c0 C\u00c1C TI\u00caU CH\u00cd QUAN TR\u1eccNG KHI THI\u1ebeT K\u1ebe PROBE TRONG REAL TIME PCR<\/a><\/h3>
\n \n \n<\/svg>\nadmin<\/a><\/span>\n \n<\/svg>\nMay 20, 2025<\/span>\n \n \n<\/svg>\n12 min read<\/span><\/div>

Probe (\u0111\u1ea7u d\u00f2) trong sinh h\u1ecdc ph\u00e2n t\u1eed l\u00e0 m\u1ed9t \u0111o\u1ea1n oligonucleotide (DNA ho\u1eb7c RNA s\u1ee3i \u0111\u01a1n) ng\u1eafn, \u0111\u01b0\u1ee3c \u0111\u00e1nh d\u1ea5u b\u1eb1ng c\u00e1c ph\u00e2n t\u1eed ph\u00e1t t\u00edn hi\u1ec7u (th\u01b0\u1eddng l\u00e0 c\u00e1c ch\u1ea5t ph\u00e1t hu\u1ef3nh quang). Probe \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3…<\/p>\n<\/div>

Read More\n \n<\/svg>\n<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
\"HPLC<\/a><\/div><\/div>
B\u00e0i vi\u1ebft<\/a>Uncategorized<\/a>\u1ee8ng d\u1ee5ng s\u1ea3n ph\u1ea9m<\/a><\/div><\/div>

HPLC L\u00e0 G\u00ec? \u1ee8ng D\u1ee5ng C\u1ee7a HPLC Trong Tinh S\u1ea1ch v\u00e0 Ph\u00e2n T\u00edch Oligonucleotide<\/a><\/h3>
\n \n \n<\/svg>\nadmin<\/a><\/span>\n \n<\/svg>\nFeb 14, 2025<\/span>\n \n \n<\/svg>\n13 min read<\/span><\/div>

HPLC (High Performance Liquid Chromatography) \u2013 S\u1eafc k\u00fd l\u1ecfng hi\u1ec7u n\u0103ng cao l\u00e0 m\u1ed9t k\u1ef9 thu\u1eadt ph\u00e2n t\u00edch \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u00e1ch, \u0111\u1ecbnh t\u00ednh ho\u1eb7c \u0111\u1ecbnh l\u01b0\u1ee3ng c\u00e1c ch\u1ea5t, th\u00e0nh ph\u1ea7n trong m\u1ed9t h\u1ed7n h\u1ee3p ch\u1ea5t l\u1ecfng.<\/p>\n<\/div>

Read More\n \n<\/svg>\n<\/a><\/div><\/div><\/div><\/div><\/div><\/div>
\"C\u00c1C<\/a><\/div><\/div>
\u1ee8ng d\u1ee5ng s\u1ea3n ph\u1ea9m<\/a>B\u00e0i vi\u1ebft<\/a><\/div><\/div>

C\u00c1C PH\u01af\u01a0NG PH\u00c1P TINH S\u1ea0CH OLIGONUCLEOTIDE<\/a><\/h3>
\n \n \n<\/svg>\nadmin<\/a><\/span>\n \n<\/svg>\nJan 15, 2025<\/span>\n \n \n<\/svg>\n9 min read<\/span><\/div>

Oligonucleotide l\u00e0 nh\u1eefng ph\u00e2n t\u1eed DNA ho\u1eb7c RNA m\u1ea1ch \u0111\u01a1n ho\u1eb7c m\u1ea1ch \u0111\u00f4i c\u00f3 k\u00edch th\u01b0\u1edbc ng\u1eafn th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c \u1ee9ng d\u1ee5ng sinh h\u1ecdc ph\u00e2n t\u1eed, y h\u1ecdc v\u00e0 nghi\u00ean c\u1ee9u khoa h\u1ecdc. C\u00e1c tr\u00ecnh t\u1ef1 oligonucleotide…<\/p>\n<\/div>

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D\u1ecbch v\u1ee5 OligoX<\/a><\/em><\/strong><\/h3>

T\u1ed5ng h\u1ee3p Oligonucleotide bao g\u1ed3m c\u00e1c s\u1ea3n ph\u1ea9m PCR, qPCR Primer, Primer\/Probe bi\u1ebfn \u0111\u1ed5i, Tr\u00ecnh t\u1ef1 RNA, Amplicon v\u00e0 c\u00e1c t\u1ed5ng h\u1ee3p \u0111\u1eb7c bi\u1ec7t<\/p><\/div>

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Ngu\u1ed3n tham kh\u1ea3o<\/strong><\/h2>\n\n\n\n
    \n
  1. The Glen Report, 1999, 12, 1-4. https:\/\/www.glenresearch.com\/reports\/gr30-24<\/a><\/li>\n\n\n\n
  2. M.S. Shchepinov, I.A. Udalova, A.J. Bridgman, and E.M. Southern, Nucleic Acids Res, 1997, 25, 4447-4454. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC147080\/<\/a><\/li>\n\n\n\n
  3. M.S. Shchepinov, K.U. Mir, J.K. Elder, M.D. Frank-Kamenetskii, and E.M. Southern, Nucleic Acids Res, 1999, 27, 3035-41.<\/li>\n\n\n\n
  4. T. Horn, and M.S. Urdea, Nucleic Acids Res, 1989, 17, 6959-67.<\/li>\n\n\n\n
  5. M.L. Collins, et al., Nucleic Acids Res, 1997, 25, 2979-84.<\/li>\n\n\n\n
  6. T. Horn, C.A. Chang, and M.S. Urdea, Nucleic Acids Res, 1997, 25, 4835-4841.<\/li>\n\n\n\n
  7. T. Horn, C.A. Chang, and M.S. Urdea, Nucleic Acids Res, 1997, 25, 4842-4849.<\/li>\n\n\n\n
  8. M.S. Shchepinov, and E.M. Southern, Russ. J. Bioorg. Chem., 1998, 24, 794.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Oligonucleotide dendrimer \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng m\u1ed9t h\u1ee3p ch\u1ea5t phosphoramidite, tris-2,2,2-[3-(4,4′-dimethoxytrityloxy) propyloxymethyl]ethyl- N , N -diisopropylaminocyanethoxy 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